Cell-Cell interaction studies in Cancer and Reproduction

Our research team studies the molecular basis of the mechanisms involved in intercellular adhesion as well as the events of intra- and intercellular signaling that are triggered as a result of cell-cell interactions in physiological and pathological processes. For more than 20 years, team members have studied various molecular processes that underlie such important pathologies as infertility and cancer. 

 

Our interest is to identify specific, sensitive and reproducible molecular markers known as biomarkers. Biomarkers are molecules found in biological tissues and fluids act as indicators of normal biological processes, pathological processes and in response to therapies or interventions. They are used to assist in the detection (biomarker diagnosis), evolution and possible recurrence (prognostic biomarker), to choose a treatment and / or to evaluate the response of a patient to the oncological (predictive biomarker) treatment of the disease and even for the design of drugs. We hope to continue our investigations, which we understand contribute to the innovative model of Personalized or Precision Medicine.This new approach to human medicine proposes the use of diagnostic and treatment approaches adjusted to the individual genetic characteristics of each patient and the disease, as well as to the patient's environmental conditions and lifestyle. Its application will increase the efficiency in the management of the patients, avoiding delays and complications that compromise the quality of life of the individuals.

 

For the translational research projects we carry out, we combine bioinformatics, cellular, molecular and functional biology strategies, using cellular models, experimental animals and samples from patients affected by various pathologies.

 

We are investigating molecular aspects related to male and female infertility and to solid tumors of epithelial origin that affect both women (ovary, endometrium) and men (prostate) and both (breast and bladder).

 

We work closely to natioanl and medical experts, among them teams from the Hospital Italiano de Buenos Aires and from the Hospital  Vall d´Hebron from Barcelona, Spain.

 

As an example of our advances, in the area of reproduction, we have identified factors that affect spermatozoa in their fertilizing potential. In the area of oncology, we have identified molecules whose detection can contribute to the diagnosis and monitoring of the severity of tumors and predict their aggressiveness (Some schemes are presented).

 

Our expertise in molecular biology and reproduction has led us to initiate in recent years a set of collaborations with colleagues in our country for the development of biosimilars using innovative strategies worldwide to generate genetically modified animals as bioreactors, which can be used in the development of biopharmaceuticals for human and animal application.

 

Cell-Cell interaction studies in Cancer and Reproduction

  • Mónica H. Vazquez-Levin Currículum Vitae

The research team

Cover September 2014 BIology of the Cell. Rosso, Lapyckyj et al.

Cover Issue October 2008 Molecular Human Reproduction. Marin Briggiler et al.

Cover Issue May 2015 Developmental Biology. Vazquez-Levin et al.

Cover Year 2012 Taurus. Vazquez-Levin et al.

Laboratories
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