Testicular Neuro-immune-endocrinology

This Laboratory is focused in the comprehension of the physio-pathology of the male reproductive axis as well as in the study of male idiopathic infertility.

Preliminary results allows us to postulate the relevance of endogenous factors with both an immune (mast cells and macrophages) and neuronal origin (nerve fibers and neuron-like cells through certain neurotransmitters, neuropeptides and neurohormones) in the maintenance of the testicular homeostasis. The testicular mast cells and macrophages have a notorious secretory capacity. Therefore, these immune cells produce and secrete prostaglandins (PGs) mediating lipids with an autocrine/paracrine action. The PGs would act on diverse cell populations through a wide variety of actions. For instance, PGs regulate androgen production in Leydig cells, glucose uptake in Sertoli cells as well as oxidative stress and cell proliferation in the male gonad.

On the other hand, aging is a natural process affecting almost all organs and tissues. In the testis, the aging process is associated with histological and morphological changes. Our investigations analyse the molecular mechanisms related to testicular aging, in particular, those involved in apoptotic, inflammatory and oxidative events.

  • Director

    Dr Mónica Frungieri

    Research Scientific and Professor - National Research Council of Αrgentina

  • Doctor

    Dr María Eugenia Matzkin

    Research Scientific - National Research Council of Argentina

  • Doctor

    Dr. Soledad Paola Rossi

    Postdoctoral Fellow - National Research Council of Argentina

  • Master of Sciences

    Msc Paula Valchi

    Doctoral Fellow - National Research Council of Argentina

  • Master of Sciences

    Msc Eugenia Riviere

    Doctoral Fellow - National Agency for Science and Technology Promotion