This Laboratory derives from those directed by Dr. Ricardo S. Calandra which is focused in the comprehension of the physio-pathology of the reproductive axis and idiopathic diseases.

Preliminary results allows us to postulate the relevance of endogenous factors with both an immune (mast cells and macrophages) and neuronal origin (nerve fibers and neuron-like cells through certain neurotransmitters, neuropeptides and neurohormones) in the maintenance of the testicular homeostasis. The testicular mast cells and macrophages have a notorious secretory capacity. Therefore, these immune cells produce and secrete prostaglandins (PGs) mediating lipids with an autocrine/paracrine action. The PGs would act on diverse cell populations through a wide variety of actions. For instance, PGs regulate androgen production in Leydig cells, glucose uptake in Sertoli cells as well as oxidative stress and cell proliferation in the male gonad.

  • Mónica Frungieri
  • María Eugenia Matzkin
  • Soledad Paola Rossi