Endometrial Pathophysiology

This lab specializes in the study of endometriosis in a context of basic/applied scientific research.The study of the endometrial pathophysiology allows us to suggest new targets for endometriosis treatment, evaluating natural compounds that could act directly on the implants by inhibiting the mechanisms involved in the development of the disease. We also study the molecular mechanisms implicated in the immune privilege that protects the growth of endometriotic tissue and the mechanisms involved in the ectopic endometrial adhesion, invasion and survival.

Endometrial Pathophysiology

  • Ph.D. Gabriela Meresman Currículum Vitae

    Head of Endometrial Pathophysiology Laboratory, Institute of Experimental Biology and Medicine (IBYME-CONICET), Buenos Aires, Argentina.

    Independent Researcher, National Research Council of Science and Technology (CONICET), Buenos Aires, Argentina.

    Associate Professor of Immunology, School of Medicine, Salvador University (USAL), Buenos Aires, Argentina.

    Director of the Postgraduate Course: “New concepts in programmed cell death (Apoptosis)”, University of Buenos Aires (UBA), Argentina

  • Ph.D. Carla Olivares

    assistant researcher (CONICET)

  • Ph.D. Juan Ignacio Bastón

    Postdoc Fellow (CONICET)

  • Doctoral Fellow

    Ms.C Luciana Ferella

Visiting Professorship Award, Hebrew University of Jerusalem, for the academic year 2015-2016. Lady Davis Professorship. Faculty of Medicine, Hebrew University of Jerusalem, Israel


Best oral presentation award LVIII Anual congress of the Argentine Society for Clinical Investigation, 2013. Galectin-1 promotes vascularization of endometriotic lesions in an experimental animal model.Bastón JI, Barañao RI, Ricci A, Bilotas M, Olivares C, Croci D, Rabinovich GA, Meresman GF. 


Dr. Peralta Ramos Best Research paper, National Academy of Medicine Award, 2011. New therapeutics for the treatment of endometriosis.Meresman GF, Bilotas M,  Olivares C, Ricci A, Bastón JI y Barañao RI.


Best Poster presentation Award, Chilean Society for Reproduction and Development, 2010. Galectin-1 promotes vascular development and growth of endometriotic-like lesions in a mouse model of endometriosis. Bastón J.I., Ricci A., Bilotas M., Olivares C., Rabinovich G.A., Barañao R.I., Meresman GF. 

Best Basic Research work, FASGO (Argentine Federation of Gynecology and Obstetrics Societies) 50th anniversary Award, 2006.Rationale for treating endometriosis with aromatase inhibitors.Meresman GF, Bilotas M, Buquet R, Sueldo C, Tesone M y Barañao RI.


Best Research work, Rossi Foundation, Annual Medicine Award, 2004. Effect of GnRH analogs on eutopic endometrium and its mechanisms.Meresman GF, Bilotas M,  Buquet R, Tesone M, Sueldo C y Barañao RI.


Mezzadra Best research work award. University of Buenos Aires Faculty of Medicine, 2004. Effects of GnRh agonists and antagonists on human endometrial tissue. Meresman GF, Bilotas M, Buquet R, Barañao RI, Sueldo C, Tesone M.


 2nd Best Scientific Work Roger Abdelmassih  Award, 2003. Roger Abdelmassih research center in human reproduction, Sao Pablo, Brazil. Effect of Gonadotropin-releasing hormone (GnRH) analogs on the apoptosis and release of IL-1b and VEGF in endometrial cell cultures from patients with endometriosis. Gabriela Meresman, Mariela A. Bilotas, Eduardo Lombardi, Marta Tesone, Carlos Sueldo, Rosa I. Barañao.


“Dr. Alberto Peralta Ramos” Best Research Paper Award, National Academy of Medicine, 2002. Pelvic Endometriosis: etiopathogenic variables and infertility. Meresman GF, Barañao RI, Bilotas M, Tesone M, Lombardi E, Auge L, Sueldo C.


Published papers from 2002
  • Bilotas M, Olivares C, Ricci A, Bastón JI, Bengochea T, Meresman G, Barañao RI. Interplay between endometriosis and pregnancy in a mouse model. Plos One 10(4):e0124900. doi: 10.1371/journal.pone.0124900. eCollection 2015. ISSN 1932-6203
  • Bastón JI, Barañao RI, Ricci AG, Bilotas M, Olivares C, Singla JJ, Gonzalez AM,  Stupirski JC, Croci D, Rabinovich GA, Meresman GF. Targeting galectin-1-induced mitigates the severity of endometriosis. The Journal of Pathology, 234(3):329-37. ISSN 0022-3417
  • Scotti L, Abramovich D, Pascuali N, Irusta G, Meresman GF, Tesone M, Parborell F. Local VEGF inhibition prevents ovarian alterations associated with ovarian hyperstimulation syndrome. J Steroid Biochem Mol Biol. 144: 392-401, 2014 ISSN 0960-0760
  • Olivares C, Bilotas M, Ricci A, Barañao RI, Meresman GFAnastrozole and celecoxibfor endometriosis treatment, good to keep them apart?Reproduction 145 (2):119-126, 2013.
  • Ricci A, Olivares C, Bilotas M, Bastón JI, Singla J, Meresman GF, Barañao RI.Natural therapies assessment for the treatment of endometriosis. Human Reproduction 2013 28(1):178-88.
  • Meresman GF y Olivares CN. Implicancia de las prostaglandinas en la fisiopatología de la endometriosis. Revista de la Sociedad Argentina de Endocrinología Ginecológica y Reproductiva (SAEGRE) Vol. XIX (3): 40-56, Noviembre de 2012.
  • Meresman GF and Olivares CN. Involvement of prostaglandins in the pathophysiology of endometriosis. Endometriosis,  Basic Concepts and Current Research Trends. InTech, ISBN: 978-953-51-0524-4, edited by Koel Chaudhury and Baidyanath Chakravarty, Chapter 7: 115-132, 2012
  • Meresman GF,  Bilotas M,  Olivares C, Ricci A, Bastón JI, Barañao RI. Caracterización del endometrio y del ambiente peritoneal de mujeres que padecen endometriosis.  Estudios in vivo e in vitro de nuevas  alternativas terapéuticas para esta enfermedad. Acta Bioquímica Clínica Latinoamericana (ABCL) 45(4):635-638, 2011
  • Meresman G.  Relevancia de la apoptosis en la reproducción femenina. Investigación Clínica (Venezuela) 52(3): 274 - 290, 2011
  • Ricci, A, Olivares, C, Bilotas, M, Meresman, GF, Barañao, RI. Effect of vascular endothelial growth factor inhibition on endometrial implant development in a murine model of endometriosis. Reproductive Sciences. 18(7):614-22, 2011
  • Olivares C, Ricci A, Bilotas M; Barañao RI; Meresman G. The inhibitory effect of celecoxib and rosiglitazone on experimental endometriosis. Fertility and Sterility, 96(2):428-33, 2011.
  • Meresman GF, Bilotas M, Olivares C, Ricci A, Bastón JI,Barañao RI. Evaluación de nuevas posibles terapias para la endometriosis. Revista SAEGRE Volumen XVIII (1): 5-16 2011
  • Meresman GF, Olivares C, Vighi S, Alfie M, Irigoyen M, Etchepareborda JJ. Apoptosis is increased and cell proliferation is decreased in out-of-phase endometria from infertile and recurrent abortion patients.  Reprod Biol Endocrinol. 8: 126-133,  2010
  • Bilotas M, Meresman GF, Buquet R, Sueldo C, Barañao RI. Effect of vascular endothelial growth factor and interleukin-1 beta on apoptosis in endometrial cell cultures from patients with endometriosis and controls. Journal of Reproductive Immunology, 84: 193-198, 2010.
  • Bilotas M, Meresman GF, Stella I, Sueldo C, Barañao RI. Effect of aromatase inhibitors on ectopic endometrial growth and peritoneal environment in a mouse model of endometriosis. Fertil Steril. 93(8): 2513-8, 2010
  • Meresman GF. Apoptosis y su impacto en la reproducción femenina. Revista SAEGRE, Volumen XVI (1): 4-14, 2009.
  • Tesone M, Bilotas M, Barañao RI, Meresman GF. The role of GnRH analogues in endometriosis-associated apoptosis and angiogenesis. Gynecol Obstet Invest 66 (suppl 1): 10-18, 2008.
  • Olivares C, Bilotas M, Buquet R, Borghi M, Sueldo C, Tesone M, Meresman GF. Effects of a selective cyclooxygenase-2 inhibitor on endometrial epithelial cells from patients with endometriosis. Human Reproduction, 23(12):2701-8, 2008
  • Bilotas M, Barañao RI, Buquet R, Sueldo C, Tesone M, Meresman GF. Effect of GnRH analogs on apoptosis and expression of Bcl-2, Bax, Fas and FasL in endometrial epithelial cultures from patients with endometriosis. Human Reproduction 22 (3): 644-653, 2007.
  • Meresman GF, Olivares C, Bilotas M, Buquet R, Sueldo C. Efecto del inhibidor selectivo de COX-2 celecoxib sobre el crecimiento del tejido endometrial eutópico en endometriosis. Bases experimentales que sustentan la búsqueda de nuevas alternativas terapéuticas para la endometriosis. Reproducción XXI (3): 55-67, 2006, Buenos Aires, Argentina.
  • Bilotas M, Meresman GF, Stella I, Sueldo C y Barañao RI. El  tratamiento con inhibidores de aromatasa reduce el tamaño de las lesiones en un modelo de endometriosis murina. Reproducción XXI (1):27-35, 2006, Buenos Aires, Argentina.
  • Vitale AM, Abramovich D, Peluffo M, Meresman GF, Tesone M. Effect of GnRH agonist and antagonist on human luteinized granulosa cells proliferation and apoptosis. Fertility and Sterility 85:1064-7, 2006.
  • Meresman GF, Bilotas M, Abello V, Buquet R, Tesone M, Sueldo C. Effects of aromatase inhibitors on proliferation and apoptosis in eutopic endometrial cell cultures from patients with endometriosis. Fertility and Sterility 84(2):459-63, 2005.
  • Meresman GF, Bilotas M, Lombardi E, Tesone M., Sueldo C, Barañao RI. Effect of Gonadotropin-releasing hormone (GnRH) analogs on the apoptosis and release of IL-1b and VEGF in endometrial cell cultures from patients with endometriosis. Human Reproduction, 18:1767-1771, 2003.
  • Meresman, GF, Buquet, RA, Bilotas, M, Barañao, RI, Sueldo, C, Tesone, M. Gonadotropin-releasing hormone agonist (GnRH-a) induces apoptosis and reduces cell proliferation in eutopic endometrial cultures from women with endometriosis. Fertility and Sterility, Vol. 80 (suppl 2):702-707, 2003.
  • Meresman GF, Auge L, Barañao RI, Lombardi E, Tesone M, Sueldo C. Oral contraceptives treatment suppresses proliferation and enhances apoptosis of eutopic endometrial tissue from patients with endometriosis. Fertility and Sterility 77(6):1141-7, 2002