Studies in Ovarian Physiopathology

Optimal follicular development is essential to obtain high-quality oocytes, which requires the formation of mature blood vessels to carry nutrients and hormones to growing follicles. Deficiencies in vascular development (angiogenesis) are implicated in many ovarian disorders, such as anovulation and infertility, pregnancy loss, premature ovarian failure (POF), polycystic  ovarian syndrome (PCOS) and ovarian hyperstimulation syndrome (OHSS). If angiogenic alterations were to be reverted in these pathological conditions, it is possible that those pathologies could be improved as well. Thus, the study of angiogenic regulation in the ovary is of utmost relevance, both in physiological and in pathological conditions.

In our laboratory, we employ a wide range of experimental techniques including animal models in rodents, cell culture and human samples from ART patients (follicular fluids).  These tools allow us to characterize pathologies with a view to identifying novel diagnostic and therapeutic strategies.

Therefore, one of the keystones of our laboratory is the combination of basic research on angiogenesis with clinical practice to improve ovarian function in cases of ovarian diseases with angiogenic alterations. Our aim is to design new therapeutics that will help alleviate these patients’ conditions.

Studies in Ovarian Physiopathology

  • Fernanda Parborell

Chorioallantoic membrane blood vessels. Green: endothelial cells. Red: periendothelial cells