{"id":10829,"date":"2023-03-31T11:36:14","date_gmt":"2023-03-31T14:36:14","guid":{"rendered":"https:\/\/ibyme.org.ar\/investigacion\/laboratories\/tumor-immunology\/research-lines\/"},"modified":"2024-06-25T16:51:54","modified_gmt":"2024-06-25T19:51:54","slug":"research-lines","status":"publish","type":"page","link":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/","title":{"rendered":"Research lines"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background fusion-parallax-none hundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-top:0px;--awb-margin-bottom:0px;--awb-min-height:300px;--awb-background-image:url(&quot;https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2023\/03\/laboratorio-header-1.jpg&quot;);--awb-background-size:cover;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"width:104% !important;max-width:104% !important;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 fusion-flex-container has-pattern-background has-mask-background lab-menu nonhundred-percent-fullwidth non-hundred-percent-height-scrolling fusion-custom-z-index\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-z-index:999;--awb-padding-top:5px;--awb-padding-bottom:5px;--awb-margin-bottom:40px;--awb-background-color:var(--awb-color8);--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><nav class=\"awb-menu awb-menu_row awb-menu_em-hover mobile-mode-collapse-to-button awb-menu_icons-left awb-menu_dc-no mobile-trigger-fullwidth-off awb-menu_mobile-toggle awb-menu_indent-left mobile-size-full-absolute loading mega-menu-loading awb-menu_desktop awb-menu_dropdown awb-menu_expand-right awb-menu_transition-fade\" style=\"--awb-font-size:15px;--awb-line-height:1.5;--awb-bg:rgba(26,23,27,0);--awb-border-radius-top-left:3px;--awb-border-radius-top-right:3px;--awb-border-radius-bottom-right:3px;--awb-border-radius-bottom-left:3px;--awb-gap:10px;--awb-align-items:center;--awb-items-padding-top:6px;--awb-items-padding-right:15px;--awb-items-padding-bottom:6px;--awb-items-padding-left:15px;--awb-color:var(--awb-color1);--awb-active-color:var(--awb-color1);--awb-active-bg:var(--awb-color4);--awb-active-border-color:var(--awb-color2);--awb-submenu-color:var(--awb-color1);--awb-submenu-bg:var(--awb-color8);--awb-submenu-sep-color:var(--awb-color8);--awb-submenu-border-radius-top-left:4px;--awb-submenu-border-radius-top-right:4px;--awb-submenu-border-radius-bottom-right:4px;--awb-submenu-border-radius-bottom-left:4px;--awb-submenu-active-bg:var(--awb-color4);--awb-submenu-active-color:var(--awb-color1);--awb-icons-color:var(--awb-color1);--awb-icons-hover-color:var(--awb-color2);--awb-main-justify-content:flex-start;--awb-mobile-justify:flex-start;--awb-mobile-caret-left:auto;--awb-mobile-caret-right:0;--awb-fusion-font-family-typography:&quot;Red Hat Display&quot;;--awb-fusion-font-style-typography:normal;--awb-fusion-font-weight-typography:400;--awb-fusion-font-family-submenu-typography:inherit;--awb-fusion-font-style-submenu-typography:normal;--awb-fusion-font-weight-submenu-typography:400;--awb-fusion-font-family-mobile-typography:inherit;--awb-fusion-font-style-mobile-typography:normal;--awb-fusion-font-weight-mobile-typography:400;\" aria-label=\"Inmunolog\u00eda Tumoral\" data-breakpoint=\"1024\" data-count=\"0\" data-transition-type=\"fade\" data-transition-time=\"300\" data-expand=\"right\"><button type=\"button\" class=\"awb-menu__m-toggle awb-menu__m-toggle_no-text\" aria-expanded=\"false\" aria-controls=\"menu-inmunologia-tumoral\"><span class=\"awb-menu__m-toggle-inner\"><span class=\"collapsed-nav-text\"><span class=\"screen-reader-text\">Toggle Navigation<\/span><\/span><span class=\"awb-menu__m-collapse-icon awb-menu__m-collapse-icon_no-text\"><span class=\"awb-menu__m-collapse-icon-open awb-menu__m-collapse-icon-open_no-text fa-bars fas\"><\/span><span class=\"awb-menu__m-collapse-icon-close awb-menu__m-collapse-icon-close_no-text fa-times fas\"><\/span><\/span><\/span><\/button><ul id=\"menu-inmunologia-tumoral-ingles\" class=\"fusion-menu awb-menu__main-ul awb-menu__main-ul_row\"><li  id=\"menu-item-10836\"  class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-10836 awb-menu__li awb-menu__main-li awb-menu__main-li_regular\"  data-item-id=\"10836\"><span class=\"awb-menu__main-background-default awb-menu__main-background-default_fade\"><\/span><span class=\"awb-menu__main-background-active awb-menu__main-background-active_fade\"><\/span><a  href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/\" class=\"awb-menu__main-a awb-menu__main-a_regular\"><span class=\"menu-text\">Home<\/span><\/a><\/li><li  id=\"menu-item-10837\"  class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-10837 awb-menu__li awb-menu__main-li awb-menu__main-li_regular\"  data-item-id=\"10837\"><span class=\"awb-menu__main-background-default awb-menu__main-background-default_fade\"><\/span><span class=\"awb-menu__main-background-active awb-menu__main-background-active_fade\"><\/span><a  href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/lab-members\/\" class=\"awb-menu__main-a awb-menu__main-a_regular\"><span class=\"menu-text\">Lab members<\/span><\/a><\/li><li  id=\"menu-item-10834\"  class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-10834 awb-menu__li awb-menu__main-li awb-menu__main-li_regular\"  data-item-id=\"10834\"><span class=\"awb-menu__main-background-default awb-menu__main-background-default_fade\"><\/span><span class=\"awb-menu__main-background-active awb-menu__main-background-active_fade\"><\/span><a  href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/lab-publications\/\" class=\"awb-menu__main-a awb-menu__main-a_regular\"><span class=\"menu-text\">Lab publications<\/span><\/a><\/li><li  id=\"menu-item-10833\"  class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-10833 awb-menu__li awb-menu__main-li awb-menu__main-li_regular\"  data-item-id=\"10833\"><span class=\"awb-menu__main-background-default awb-menu__main-background-default_fade\"><\/span><span class=\"awb-menu__main-background-active awb-menu__main-background-active_fade\"><\/span><a  href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/blog\/\" class=\"awb-menu__main-a awb-menu__main-a_regular\"><span class=\"menu-text\">Blog<\/span><\/a><\/li><li  id=\"menu-item-10832\"  class=\"menu-item menu-item-type-post_type menu-item-object-page menu-item-10832 awb-menu__li awb-menu__main-li awb-menu__main-li_regular\"  data-item-id=\"10832\"><span class=\"awb-menu__main-background-default awb-menu__main-background-default_fade\"><\/span><span class=\"awb-menu__main-background-active awb-menu__main-background-active_fade\"><\/span><a  href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/contact\/\" class=\"awb-menu__main-a awb-menu__main-a_regular\"><span class=\"menu-text\">Contact<\/span><\/a><\/li><\/ul><\/nav><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><nav class=\"fusion-breadcrumbs awb-yoast-breadcrumbs fusion-breadcrumbs-1\" style=\"--awb-alignment:left;--awb-breadcrumb-sep:&#039;\/&#039;;text-align:left;\" aria-label=\"Breadcrumb\"><span><span><a href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/\">Inicio<\/a><\/span><\/span><\/nav><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-one\" style=\"--awb-text-color:var(--awb-color8);\"><h1 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Tumor Immunology<\/h1><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-4 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-text-color:var(--awb-color5);--awb-font-size:22px;\"><h2 class=\"fusion-title-heading title-heading-left\" style=\"font-family:&quot;Red Hat Display&quot;;font-style:normal;font-weight:700;margin:0;font-size:1em;\">Research lines<\/h2><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-5 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>We study of interactions of growth factors, cytokines and hormones in breast cancer, a field in which we have made original contributions at the international level.<\/p>\n<p>The laboratory has exhaustively characterized the mechanisms involved in proliferation induced by progestins in breast cancer. We have shown that breast cancer cell proliferation is driven by the bidirectional interaction between progestins and growth factors. We are currently studying the nuclear function of ErbB-2 and the therapeutic relevance of its inhibition in breast cancer. We demonstrated that both heregulin (an ErbBs ligand) and progestins induce nuclear ErbB-2 migration, which stimulates cell proliferation. By using an ErbB-2 mutant that is unable to translocate to the nucleus (called hErbB-2\u2206NLS mutant), we were able to inhibit the growth of breast carcinomas. We also revealed that the nuclear function of ErbB-2 is involved in resistance to the action of trastuzumab. Indeed, we demonstrated that blockade of nuclear ErbB-2 localization suppresses tumor growth in a preclinical model of resistance to trastuzumab and would constitute a novel therapeutic strategy for the treatment of these tumors. We also found that the role of nuclear ErbB-2 as a transcription factor coactivator and its direct role as transcription factor upregulate microRNA-21 (miR-21) and promote BC metastasis. Our findings challenge the paradigm of anti-ErbB-2 drug design and highlight nuclear ErbB-2 as a novel target to overcome Ttzm resistance. Likewise, we have shown that the nuclear function of ErbB-2 is essential for the growth of triple-negative breast cancer and that nuclear ErbB-2 expression is a biomarker of poor clinical outcome in these patients. We continue exploring the molecular mechanisms through which ErbB-2 exerts its nuclear functions.<\/p>\n<p>Tumor Immunology Group<br \/>\nWe have demonstrated that the expression of the glycoprotein mucin 4 (MUC4) in HER2 positive breast cancer cells induces resistance to trastuzumab. We have determined that tumor necrosis alpha (TNF\u03b1), a proinflammatory cytokine, is the responsible of increasing MUC4 expression in HER2 positive breast cancer tumors. TNF\u03b1 blockade, using antibodies against TNF\u03b1 that are used in the clinic to treat inflammatory diseases such as rheumatoid arthritis among others, sensitizes HER2 positive tumors to trastuzumab and mounts an effective antitumoral immune response. We have also shown that MUC4 expression in HER2 positive breast cancer samples is an independent biomarker of poor trastuzumab response. Given these results, we are currently working on establishing the determination of MUC4 expression as a biomarker for HER2 and MUC4 positive breast cancer patients to assign the anti-HER2 therapies in combination with TNF\u03b1 blocking agents to avoid or overcome resistance to treatment.<\/p>\n<\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":29,"featured_media":0,"parent":10812,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"100-width.php","meta":{"_acf_changed":false,"inline_featured_image":false,"wpupg_custom_link":[],"wpupg_custom_link_behaviour":[],"wpupg_custom_link_nofollow":[],"wpupg_custom_image":[],"wpupg_custom_image_id":[],"footnotes":""},"page_category":[],"class_list":["post-10829","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research lines - IBYME<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research lines - IBYME\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/\" \/>\n<meta property=\"og:site_name\" content=\"IBYME\" \/>\n<meta property=\"article:modified_time\" content=\"2024-06-25T19:51:54+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"22 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/\",\"url\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/\",\"name\":\"Research lines - IBYME\",\"isPartOf\":{\"@id\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/#website\"},\"datePublished\":\"2023-03-31T14:36:14+00:00\",\"dateModified\":\"2024-06-25T19:51:54+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Inicio\",\"item\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Laboratories\",\"item\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Tumor Immunology\",\"item\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Research lines\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/#website\",\"url\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/\",\"name\":\"IBYME\",\"description\":\"Instituto de Biolog\u00eda y Medicina Experimental\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ibyme.org.ar\/investigacion\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Research lines - IBYME","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/","og_locale":"en_US","og_type":"article","og_title":"Research lines - IBYME","og_url":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/","og_site_name":"IBYME","article_modified_time":"2024-06-25T19:51:54+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"22 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/","url":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/","name":"Research lines - IBYME","isPartOf":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#website"},"datePublished":"2023-03-31T14:36:14+00:00","dateModified":"2024-06-25T19:51:54+00:00","breadcrumb":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/research-lines\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Inicio","item":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/"},{"@type":"ListItem","position":2,"name":"Laboratories","item":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/"},{"@type":"ListItem","position":3,"name":"Tumor Immunology","item":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/tumor-immunology\/"},{"@type":"ListItem","position":4,"name":"Research lines"}]},{"@type":"WebSite","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#website","url":"https:\/\/ibyme.org.ar\/investigacion\/en\/","name":"IBYME","description":"Instituto de Biolog\u00eda y Medicina Experimental","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibyme.org.ar\/investigacion\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/pages\/10829","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/comments?post=10829"}],"version-history":[{"count":2,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/pages\/10829\/revisions"}],"predecessor-version":[{"id":10831,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/pages\/10829\/revisions\/10831"}],"up":[{"embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/pages\/10812"}],"wp:attachment":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/media?parent=10829"}],"wp:term":[{"taxonomy":"page_category","embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/page_category?post=10829"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}