{"id":12952,"date":"2026-03-27T15:45:15","date_gmt":"2026-03-27T18:45:15","guid":{"rendered":"https:\/\/ibyme.org.ar\/investigacion\/?p=12952"},"modified":"2026-03-27T15:45:15","modified_gmt":"2026-03-27T18:45:15","slug":"mencion-al-merito-del-premio-bienal-florencio-fiorini-en-cancer-2025","status":"publish","type":"post","link":"https:\/\/ibyme.org.ar\/investigacion\/en\/mencion-al-merito-del-premio-bienal-florencio-fiorini-en-cancer-2025\/","title":{"rendered":"Menci\u00f3n al M\u00e9rito del Premio Bienal Florencio Fiorini en C\u00e1ncer 2025"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-content-alignment:justify;\"><p>El pasado 13 de marzo, en una ceremonia realizada en LALCEC, nuestro equipo fue distinguido con <strong>la Menci\u00f3n al M\u00e9rito del Premio Bienal Florencio Fiorini sobre Investigaci\u00f3n en C\u00e1ncer A\u00f1o 2025<\/strong> por el trabajo titulado \u201cMejora de la eficacia terap\u00e9utica en c\u00e1ncer de mama HER2 positivo mediante un biomarcador para una nueva terapia dirigida\u201d. El reconocimiento destaca no s\u00f3lo la calidad cient\u00edfica del estudio, sino tambi\u00e9n su potencial impacto en la pr\u00e1ctica cl\u00ednica y pone de relieve la importancia de la colaboraci\u00f3n interdisciplinaria ya que este trabajo fue realizado por Roxana Schillaci (IBYME), Sofia Bruni (IBYME), Marla Ladera Gomez (IBYME), Camila Jencquel (IBYME), Gloria Inurrigarro (Hospital Marie Curie, Hospital Austral y Sanatorio Mater Dei), , Agustina Dupont (Hospital de Agudos Juan A. Fern\u00e1ndez), Agustina Badalini, Daniel Lopez Della Vecchia (Hospital de Agudos Juan A. Fern\u00e1ndez), Sabrina Barchuk (Hospital de Agudos Juan A. Fern\u00e1ndez),Silvina Figurelli (Hospital de Agudos Juan A. Fern\u00e1ndez), Ernesto Gil Deza (Instituto Oncol\u00f3gico Henry Moore) y Mar\u00eda Florencia Mercogliano (IBYME).<\/p>\n<p>En Argentina, el c\u00e1ncer de mama contin\u00faa siendo la principal causa de muerte por tumores malignos en mujeres. Dentro de este grupo, el subtipo HER2 positivo representa aproximadamente el 20% de los casos y, si bien el tratamiento con el anticuerpo antiHER2 trastuzumab ha mejorado significativamente el pron\u00f3stico, una proporci\u00f3n relevante de pacientes desarrolla resistencia. Comprender y revertir este fen\u00f3meno es clave para avanzar hacia terapias m\u00e1s efectivas.<\/p>\n<p>Nuestro trabajo identific\u00f3 un mecanismo central de resistencia: la citoquina proinflamatoria TNF promueve la expresi\u00f3n de mucina 4 (MUC4), una glicoprote\u00edna que \u201coculta\u201d el sitio de uni\u00f3n del trastuzumab en el HER2, limitando su eficacia. A partir de este hallazgo, demostramos que el bloqueo del TNF permite revertir esta resistencia, tanto en modelos celulares como precl\u00ednicos. Esta estrategia no solo mejora la respuesta terap\u00e9utica, sino que tambi\u00e9n favorece un microambiente tumoral m\u00e1s activo inmunol\u00f3gicamente, con participaci\u00f3n de macr\u00f3fagos M1-like y c\u00e9lulas NK.<\/p>\n<p>Un aspecto particularmente relevante del estudio es la validaci\u00f3n de MUC4 como biomarcador de mala respuesta al tratamiento y su asociaci\u00f3n con tumores inmunol\u00f3gicamente \u201cfr\u00edos\u201d, con baja infiltraci\u00f3n de linfocitos. Esto abre la posibilidad de utilizar MUC4 como herramienta para guiar decisiones terap\u00e9uticas en el futuro.<\/p>\n<p>En conjunto, estos hallazgos sientan las bases para el desarrollo de futuros ensayos cl\u00ednicos que integren bloqueo de TNF con terapias anti-HER2, incorporando a MUC4 como biomarcador predictivo.<\/p>\n<p>Este reconocimiento refuerza nuestro compromiso de desarrollar tratamientos m\u00e1s eficaces, accesibles y mejor tolerados, y pone en valor que comprender la resistencia es el punto de partida para nuevas estrategias terap\u00e9uticas. En ese cruce entre biolog\u00eda tumoral, sistema inmune y tratamiento seguimos enfocando nuestro trabajo.<\/p>\n<\/div><div class=\"fusion-image-carousel fusion-image-carousel-fixed fusion-image-carousel-1 fusion-carousel-border\"><div class=\"awb-carousel awb-swiper awb-swiper-carousel\" data-autoplay=\"no\" data-columns=\"5\" data-itemmargin=\"13\" data-itemwidth=\"180\" data-touchscroll=\"no\" data-imagesize=\"fixed\"><div class=\"swiper-wrapper awb-image-carousel-wrapper fusion-flex-align-items-center\"><div class=\"swiper-slide\"><div class=\"fusion-carousel-item-wrapper\"><div class=\"fusion-image-wrapper hover-type-none\"><img decoding=\"async\" width=\"320\" height=\"202\" src=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2026\/03\/PILALCEC25_Mencion_Equipo-IByme_a_WEB-320x202.jpg\" class=\"attachment-blog-medium size-blog-medium\" alt=\"\" \/><\/div><\/div><\/div><div class=\"swiper-slide\"><div class=\"fusion-carousel-item-wrapper\"><div class=\"fusion-image-wrapper hover-type-none\"><img decoding=\"async\" width=\"320\" height=\"202\" src=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2026\/03\/Fiorini_web-1-320x202.jpg\" class=\"attachment-blog-medium size-blog-medium\" alt=\"\" \/><\/div><\/div><\/div><div class=\"swiper-slide\"><div class=\"fusion-carousel-item-wrapper\"><div class=\"fusion-image-wrapper hover-type-none\"><img decoding=\"async\" width=\"320\" height=\"202\" src=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2026\/03\/IBYME-Lab-Schillaci-Premio-C-320x202.jpg\" class=\"attachment-blog-medium size-blog-medium\" alt=\"\" \/><\/div><\/div><\/div><div class=\"swiper-slide\"><div class=\"fusion-carousel-item-wrapper\"><div class=\"fusion-image-wrapper hover-type-none\"><img decoding=\"async\" width=\"320\" height=\"202\" src=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2026\/03\/PILALCEC25_Mencion_Schillaci_a_WEB-320x202.jpg\" class=\"attachment-blog-medium size-blog-medium\" alt=\"\" \/><\/div><\/div><\/div><\/div><div class=\"awb-swiper-button awb-swiper-button-prev\"><i class=\"awb-icon-angle-left\" aria-hidden=\"true\"><\/i><\/div><div class=\"awb-swiper-button awb-swiper-button-next\"><i class=\"awb-icon-angle-right\" aria-hidden=\"true\"><\/i><\/div><\/div><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":29,"featured_media":12957,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"wpupg_custom_link":[],"wpupg_custom_link_behaviour":[],"wpupg_custom_link_nofollow":[],"wpupg_custom_image":[],"wpupg_custom_image_id":[],"footnotes":""},"categories":[329],"tags":[],"class_list":["post-12952","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inmunologia-tumoral"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - 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