{"id":13150,"date":"2025-02-02T12:50:29","date_gmt":"2025-02-02T15:50:29","guid":{"rendered":"https:\/\/ibyme.org.ar\/investigacion\/?p=13150"},"modified":"2026-07-20T18:55:02","modified_gmt":"2026-07-20T21:55:02","slug":"publicacion-en-traslational-oncology","status":"publish","type":"post","link":"https:\/\/ibyme.org.ar\/investigacion\/en\/publicacion-en-traslational-oncology\/","title":{"rendered":"Publicaci\u00f3n en Traslational Oncology"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\"><p>En el <a href=\"https:\/\/ibyme.org.ar\/investigacion\/laboratorios\/inmunologia-tumoral\/\">Laboratorio de Inmunolog\u00eda Tumoral<\/a> publicamos recientemente el trabajo <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1936523325000567?via%3Dihub\"><em>\u201cMucin 4 expression is associated with metastasis in triple-negative breast cancer and can be tackled by soluble TNF blockade, improving immunotherapy outcome\u201d<\/em><\/a> en la revista Translational Oncology. El estudio, fruto de la tesis doctoral de Florencia Mauro, analiza el rol de MUC4, una mucina asociada a progresi\u00f3n tumoral y resistencia terap\u00e9utica, en c\u00e1ncer de mama triple negativo (TNBC), uno de los subtipos m\u00e1s agresivos.<\/p>\n<p>Los resultados mostraron que la expresi\u00f3n de MUC4 se asocia con menor infiltraci\u00f3n linfocitaria, mayor capacidad metast\u00e1sica y peor sobrevida global en pacientes con TNBC. Adem\u00e1s, el trabajo demuestra que el bloqueo del TNF\u03b1 soluble reduce la expresi\u00f3n de MUC4 en modelos precl\u00ednicos y, en combinaci\u00f3n con inmunoterapia anti-PD-1, disminuye la formaci\u00f3n de met\u00e1stasis pulmonares y mejora la sobrevida en modelos murinos.<\/p>\n<p>El estudio tambi\u00e9n aporta evidencia sobre la relaci\u00f3n entre inflamaci\u00f3n, inmunosupresi\u00f3n y progresi\u00f3n metast\u00e1sica, sugiriendo que el eje TNF\/MUC4 podr\u00eda representar una estrategia terap\u00e9utica potencialmente relevante en TNBC. Asimismo, los hallazgos respaldan el estudio de MUC4 como posible biomarcador asociado a pron\u00f3stico y respuesta a inmunoterapia.<\/p>\n<p>Mauro, F., Bruni, S., Dupont, A., Schey, A., Badalini, A., Inurrigarro, G., Figurelli, S., Barchuk, S., Vecchia, D. L. D., Deza, E. G., Rivenson, Y., Nava, A., Fernandez, E., Urtreger, A., Russo, R. C., Mercogliano, M. F., &amp; Schillaci, R. (2025). Mucin 4 expression is associated with metastasis in triple-negative breast cancer and can be tackled by soluble TNF blockade, improving immunotherapy outcome. Translational oncology, 54, 102325. <a href=\"https:\/\/doi.org\/10.1016\/j.tranon.2025.102325\">https:\/\/doi.org\/10.1016\/j.tranon.2025.102325<\/a>.<\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_2 1_2 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:50%;--awb-margin-top-large:0px;--awb-spacing-right-large:3.84%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:3.84%;--awb-width-medium:50%;--awb-order-medium:0;--awb-spacing-right-medium:3.84%;--awb-spacing-left-medium:3.84%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-image-element awb-imageframe-style awb-imageframe-style-above awb-imageframe-style-1\" style=\"--awb-caption-title-color:#000000;--awb-caption-text-size:14px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:14px;--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><div class=\"awb-imageframe-caption-container\" style=\"text-align:left;\"><div class=\"awb-imageframe-caption\"><h2 class=\"awb-imageframe-caption-title\">Resumen gr\u00e1fico del trabajo<\/h2><\/div><\/div><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><a href=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model-300x177.jpg\" class=\"fusion-lightbox\" data-rel=\"iLightbox[98c47c0e9b352c0233b]\" data-title=\"Working_model\" title=\"Working_model\"><img decoding=\"async\" width=\"300\" height=\"177\" src=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model-300x177.jpg\" alt class=\"img-responsive wp-image-13253\" srcset=\"https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model-200x118.jpg 200w, https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model-400x236.jpg 400w, https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model-600x354.jpg 600w, https:\/\/ibyme.org.ar\/investigacion\/wp-content\/uploads\/2025\/02\/Working_model.jpg 715w\" sizes=\"(max-width: 640px) 100vw, 600px\" \/><\/a><\/span><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":29,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"wpupg_custom_link":[],"wpupg_custom_link_behaviour":[],"wpupg_custom_link_nofollow":[],"wpupg_custom_image":[],"wpupg_custom_image_id":[],"footnotes":""},"categories":[329],"tags":[],"class_list":["post-13150","post","type-post","status-publish","format-standard","hentry","category-inmunologia-tumoral"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Publicaci\u00f3n en Traslational Oncology - IBYME<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Publicaci\u00f3n en Traslational Oncology - IBYME\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/\" \/>\n<meta property=\"og:site_name\" content=\"IBYME\" \/>\n<meta property=\"article:published_time\" content=\"2025-02-02T15:50:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-20T21:55:02+00:00\" \/>\n<meta name=\"author\" content=\"Maria Florencia Mercogliano\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Maria Florencia Mercogliano\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/\"},\"author\":{\"name\":\"Maria Florencia Mercogliano\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/#\\\/schema\\\/person\\\/09e03353dfddf9ccc263dc79e6228203\"},\"headline\":\"Publicaci\u00f3n en Traslational Oncology\",\"datePublished\":\"2025-02-02T15:50:29+00:00\",\"dateModified\":\"2026-07-20T21:55:02+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/\"},\"wordCount\":2153,\"articleSection\":[\"Inmunolog\u00eda Tumoral\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/\",\"url\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/\",\"name\":\"Publicaci\u00f3n en Traslational Oncology - IBYME\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/#website\"},\"datePublished\":\"2025-02-02T15:50:29+00:00\",\"dateModified\":\"2026-07-20T21:55:02+00:00\",\"author\":{\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/#\\\/schema\\\/person\\\/09e03353dfddf9ccc263dc79e6228203\"},\"breadcrumb\":{\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/publicacion-en-traslational-oncology\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Inicio\",\"item\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/laboratories\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publicaci\u00f3n en Traslational Oncology\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/\",\"name\":\"IBYME\",\"description\":\"Instituto de Biolog\u00eda y Medicina Experimental\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/#\\\/schema\\\/person\\\/09e03353dfddf9ccc263dc79e6228203\",\"name\":\"Maria Florencia Mercogliano\",\"url\":\"https:\\\/\\\/ibyme.org.ar\\\/investigacion\\\/en\\\/author\\\/labschillaci\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Publicaci\u00f3n en Traslational Oncology - IBYME","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/","og_locale":"en_US","og_type":"article","og_title":"Publicaci\u00f3n en Traslational Oncology - IBYME","og_url":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/","og_site_name":"IBYME","article_published_time":"2025-02-02T15:50:29+00:00","article_modified_time":"2026-07-20T21:55:02+00:00","author":"Maria Florencia Mercogliano","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Maria Florencia Mercogliano","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/#article","isPartOf":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/"},"author":{"name":"Maria Florencia Mercogliano","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#\/schema\/person\/09e03353dfddf9ccc263dc79e6228203"},"headline":"Publicaci\u00f3n en Traslational Oncology","datePublished":"2025-02-02T15:50:29+00:00","dateModified":"2026-07-20T21:55:02+00:00","mainEntityOfPage":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/"},"wordCount":2153,"articleSection":["Inmunolog\u00eda Tumoral"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/","url":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/","name":"Publicaci\u00f3n en Traslational Oncology - IBYME","isPartOf":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#website"},"datePublished":"2025-02-02T15:50:29+00:00","dateModified":"2026-07-20T21:55:02+00:00","author":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#\/schema\/person\/09e03353dfddf9ccc263dc79e6228203"},"breadcrumb":{"@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/ibyme.org.ar\/investigacion\/publicacion-en-traslational-oncology\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Inicio","item":"https:\/\/ibyme.org.ar\/investigacion\/en\/laboratories\/"},{"@type":"ListItem","position":2,"name":"Publicaci\u00f3n en Traslational Oncology"}]},{"@type":"WebSite","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#website","url":"https:\/\/ibyme.org.ar\/investigacion\/en\/","name":"IBYME","description":"Instituto de Biolog\u00eda y Medicina Experimental","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ibyme.org.ar\/investigacion\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/ibyme.org.ar\/investigacion\/en\/#\/schema\/person\/09e03353dfddf9ccc263dc79e6228203","name":"Maria Florencia Mercogliano","url":"https:\/\/ibyme.org.ar\/investigacion\/en\/author\/labschillaci\/"}]}},"_links":{"self":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/posts\/13150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/comments?post=13150"}],"version-history":[{"count":12,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/posts\/13150\/revisions"}],"predecessor-version":[{"id":13258,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/posts\/13150\/revisions\/13258"}],"wp:attachment":[{"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/media?parent=13150"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/categories?post=13150"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibyme.org.ar\/investigacion\/en\/wp-json\/wp\/v2\/tags?post=13150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}