{"id":13145,"date":"2025-05-03T11:59:27","date_gmt":"2025-05-03T14:59:27","guid":{"rendered":"https:\/\/ibyme.org.ar\/investigacion\/?p=13145"},"modified":"2026-05-21T13:29:21","modified_gmt":"2026-05-21T16:29:21","slug":"el-laboratorio-de-inmunologia-tumoral-en-aacr-2025","status":"publish","type":"post","link":"https:\/\/ibyme.org.ar\/investigacion\/el-laboratorio-de-inmunologia-tumoral-en-aacr-2025\/","title":{"rendered":"El Laboratorio de Inmunolog\u00eda Tumoral en AACR 2025"},"content":{"rendered":"

El Laboratorio de Inmunolog\u00eda Tumoral<\/a> present\u00f3 el trabajo titulado \u201cSoluble TNF blockade enhances trastuzumab-deruxtecan innate antitumor immune response in HER2-positive breast cancer through cGAS\/STING pathway\u201d<\/a> en la reuni\u00f3n anual de la American Association for Cancer Research <\/em>(AACR) 2025. El estudio demuestra c\u00f3mo el bloqueo del TNF\u03b1 soluble, una citoquina proinflamatoria, potencia la actividad biol\u00f3gica de trastuzumab-deruxtecan (T-DXd), un anticuerpo conjugado a drogas utilizado en c\u00e1ncer de mama HER2 positivo. Los resultados obtenidos en modelos precl\u00ednicos mostraron que la combinaci\u00f3n incrementa la respuesta antitumoral e induce la activaci\u00f3n de v\u00edas inmunol\u00f3gicas asociadas a cGAS\/STING. Estos hallazgos son relevantes dado que, a pesar de la alta eficacia cl\u00ednica de T-DXd, los efectos adversos asociados al tratamiento pueden limitar su utilizaci\u00f3n. En este contexto, el estudio mostr\u00f3 que la combinaci\u00f3n permiti\u00f3 mantener la actividad biol\u00f3gica del tratamiento utilizando dosis hasta cuatro veces menores en modelos experimentales de c\u00e1ncer de mama HER2 positivo.<\/p>\n

La Lic. Mariel Fusco del Laboratorio de Imunobiolog\u00eda del C\u00e1ncer<\/a> del IIMT-CONICET-Austral<\/a> obtuvo la beca Global Scholar-in-Training Award (GSITA) de la AACR.\u00a0 Present\u00f3 resultados sobre como la hipoxia tumoral favorece la expresi\u00f3n de CAIX y HIF1\u03b1 en c\u00e1ncer de pulm\u00f3n, promoviendo la acidificaci\u00f3n del microambiente tumoral e inmunosupresi\u00f3n. En modelos precl\u00ednicos, el tratamiento con 4-metilumbeliferona (4Mu) redujo los niveles de CAIX, restaur\u00f3 el pH y disminuy\u00f3 el lactato en condiciones hip\u00f3xicas. Adem\u00e1s, la combinaci\u00f3n de 4Mu con anti-PD-1 increment\u00f3 la infiltraci\u00f3n de linfocitos T y mejor\u00f3 efecto antitumoral. Estos resultados sugieren que la modulaci\u00f3n metab\u00f3lica del microambiente tumoral podr\u00eda contribuir a optimizar la respuesta a inmunoterapias en c\u00e1ncer de pulm\u00f3n.<\/p>\n

Adem\u00e1s, durante el mismo congreso, la Dra. Mar\u00eda Florencia Mercogliano recibi\u00f3 el subsidio MONARCA otorgado por la AACR por el proyecto titulado \u201cPredictive biomarkers for HER2+ breast cancer using spatial transcriptomics\u201d. El proyecto propone estudiar biomarcadores mediante transcript\u00f3mica espacial con el objetivo de identificar perfiles asociados a respuesta terap\u00e9utica en c\u00e1ncer de mama HER2 positivo y contribuir al desarrollo de estrategias de medicina personalizada que permitan la selecci\u00f3n de pacientes al diagn\u00f3stico.<\/p>\n<\/div>

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<\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":29,"featured_media":13137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"wpupg_custom_link":[],"wpupg_custom_link_behaviour":["default"],"wpupg_custom_link_nofollow":["default"],"wpupg_custom_image":[],"wpupg_custom_image_id":[],"footnotes":""},"categories":[329],"tags":[],"class_list":["post-13145","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-inmunologia-tumoral"],"acf":[],"yoast_head":"\nEl Laboratorio de Inmunolog\u00eda Tumoral en AACR 2025 - IBYME<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ibyme.org.ar\/investigacion\/el-laboratorio-de-inmunologia-tumoral-en-aacr-2025\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"El Laboratorio de Inmunolog\u00eda Tumoral en AACR 2025 - 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