Proteoglycan and Extracellular Matrix Chemistry2024-06-12T16:58:16-03:00

Proteoglycan and Extracellular Matrix Chemistry

The laboratory is dedicated to two main lines of study: 1- breast and prostate cancer and, 2- human and murine reproduction. In the first, we are interested in knowing how the cellular environment that surrounds malignant cells is capable of modifying their behavior, taking into account that this environment is mainly composed of adipose tissue. This adipose tissue comes in two main variants: white and beige. The first is the classic adipose tissue that accumulates lipids and has an endocrine function. The second variant is fundamentally dedicated to energy function and seems to be the one that undergoes the most changes in the face of a tumor state. We are interested in seeing if there is a bidirectional regulation between both compartments of the mammary gland. Regarding prostate cancer, we are analyzing the various protein components of periprostatic adipose tissue (which surrounds the epithelium of the prostate) and the metabolic pathways that could be involved in differentiating a cancerous state from benign hyperplasia. Regarding the issue of reproduction, we are now focused on the role that moderate intake of ethanol in drinking water may have on the reproductive function of male mice and their offspring, both male and female. This has a direct transfer to clinical practice, fundamentally for clinics that receive patients with reproductive problems.

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Research area laboratories

Reproduction
Oncology
Endocrinology

Proteoglycan and Extracellular Matrix Chemistry

Dr. Juan Carlos Calvo

Endocrinology

Hormonal Physiology and Pathology

Dra. Graciela Susana Diaz-Torga

Oncology
Neurosciences
Endocrinology
Cell Biology

Nuclear Receptors

Dr. Mario D. Galigniana

Neurosciences
Endocrinology

Nociception and Neuropathic Pain

Dra. Susana Laura González

Oncology
Endocrinology

Hormonal Carcinogenesis

Dra. Claudia Lanari

Reproduction
Endocrinology

Endometrial Pathophysiology

Dra. Gabriela Meresman

Reproduction
Oncology
Endocrinology

Studies of the Physiopathology of the Ovary

Dra. María Fernanda Parborell

Endocrinology

Molecular Endocrinology and Signal Transduction

Dr. Omar Pedro Pignataro

Endocrinology
Cell Biology

Nuclear Architecture

Dra. Graciela Piwien Pilipuk

Reproduction
Endocrinology

Hormonal regulation in Reproduction

Dra. Patricia Saragüeta

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